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Solubilization technology for insoluble drugs
Insoluble Drug Solubilization Technology
At present, the main methods for solubilizing insoluble drugs include cyclodextrin inclusion technology, solid dispersion technology, adding solubilizer or co-solvent technology, synthesis of water-soluble precursors, preparation of nano-suspension, hot melt extrusion technology of liposome, etc。The company has established mature hot melt extrusion, spray drying and other drug solubilization technologies, and successfully delivered related projects。
Application of solubilization technology for insoluble drugs
● Hot melt extrusion: Hot melt extrusion technology (HME) is suitable for thermostable drugs and is often used to prepare amorphous solid dispersions to improve the bioavailability of insoluble drugs。 The low cost, which can be used for drugs with low solvent solubility and poor solvent stability, is the advantage of hot melt extrusion compared with spray drying dispersions。 热熔挤出技术还可用于缓控释制剂的制备； 热熔挤出技术可提供灵活多样的制剂方案，从而达到理想的给药目的。 Representative product: Posaconazole enteric-coated tablet。
● Spray drying: Spray drying is a process in which raw materials and carrier solution are sprayed into a chamber controlled by temperature, humidity and fluid conditions in the form of fine droplets for volatilization and drying to form a solid dispersion. Spray drying can significantly improve the dissolution rate of insoluble drugs and improve bioavailability in vivo。 Representative drugs: Apatamide tablets, telmisartan tablets。
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